Young picked up a calf injury ahead of this weekend's 3-0 win buy fifa 16 ultimate team coins more than Everton and has not recovered in time to make the squad for the trip to Russia.
Wilson, meanwhile, is getting plagued by illness and can not travel either, while long-term absentees Luke Shaw and Paddy McNair are also unavailable.
"It's the identical quantity of injuries so Luke Shaw, Paddy McNair and Ashley Young usually are not going with us," Van Gaal told MUTV.
"Willo was a little bit bit ill Wilson as he's named but, for us, it is Willo so he shall not travel with us.
"I'll take 20 players with me. It is a four-hour flight so, if a player gets ill, I've the other player in my atmosphere."
Meanwhile, Sergio Romero and Antonio Valencia return to the squad after they were rested against Everton following their World Cup qualifying exertions in South America.
"Of course that was the cause Romero and Valencia have been absent," Van Gaal stated.
"They have to cope together with the jet-lag so I did not believe it was wise to take them with us against Everton."
United have collected 3 points from their opening two Group B fixtures, beating Wolfsburg 2-1 immediately after losing by the same scoreline at PSV on matchday one.
Regardless of missing the weekend win over AFC Bournemouth, Vincent Kompany is match sufficient to face Sevilla , Manchester City boss Manuel Pellegrini has confirmed.
Pellegrini was angry that Kompany played in Belgium's final Euro 2016 qualifier against Israel regardless of struggling having a calf challenge, and he opted to leave the centre-back on the bench for Saturday's 5-1 victory.
Pellegrini has confirmed that Kompany is prepared to play in Wednesday's Champions League clash, however, whilst Aleksandar Kolarov can also be within the squad.
"Vincent was match for the final game. Aleks is match so is within the squad list," mentioned the former Villarreal boss. "[Gael] Clichy, [Fabian] Delph, Sergio Aguero and David Silva are injured."
Pellegrini confirmed that Aguero, who damaged a hamstring even though on Argentina duty, will surely face a month around the sidelines - but there is improved news regarding City's other injured trio.
"Aguero is out to get a month. Maybe subsequent week Clichy, Delph and Silva will likely be match," he mentioned.
Pellegrini has backed Wilfried Bony - who netted twice against Bournemouth - to continue his goalscoring kind for City against a Sevilla side he expects to create a stern test in the Etihad Stadium.
"Bony can play with or without having Kun - Aguero does not need to be missing for him to play. He's a important player for this squad," he continued.
"Maybe everyone thought that Sevilla could be much better within the Spanish league at this moment. They've perhaps not began properly however they beat Barcelona so it's not quick.
"I spoke using the players this morning, we're confident we'll play against the genuine Sevilla tomorrow it is distinctive for the domestic league.
"I am confident we are going to see them qualified for the following Champions League in the finish on the season. They are an essential team.
"Tomorrow we've got to win here at house against a complicated team each of the other factors are just statistics and history and won't aid us to win."